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Why this small city is the ‘eyeglasses capital’ of Japan
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Japan is famed for its skilled artisans, masters who maintain a commitment to tradition while modernizing production techniques in line with the development of new materials and processes.
Many places in the country have grown famous by focusing on specific crafts, from exquisite kimonos to perfectly designed knives. Among them is the small city of Sabae, in Fukui prefecture, about a 3.5-hour train ride from Tokyo. https://omgto3.com
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It’s widely known as Japan’s eyeglasses capital – and for good reason. Sabae produces over 90% of the frames manufactured in the country, according to the local government. Signs and objects shaped like eyeglasses can be found on city streets, and there’s even a museum and festival devoted to spectacles.
The art of making spectacles
Sabae, located on Japan’s main Honshu island near the city of Fukui, has been producing quality eyewear for more than a century.
It all started in 1905, when a local government official invited skilled eyeglasses artisans to come to the city to teach their craft, an attempt to create new opportunities for local farmers.
The move paid off. Today, Sabae has over 100 companies that collaborate to make pairs of glasses.
Though these studios use cutting-edge machinery to produce new frames made of metal and acetate, most stages still require the skilled hands and trained eyes of Sabae’s master artisans.
That includes Takeshi Yamae, a frame designer with Japanese brand Boston Club who has lived in the city for 17 years. He tells CNN one pair of glasses can involve more than 200 steps.
“I first design it, sketch it, then put it into my computer,” he says. “From the time I start designing, to the time I have the perfect product, it takes more than a year.”
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How a drab Soviet metropolis became Central Asia’s capital of cool
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
Since the collapse of the USSR, Kazakhstan’s largest city (population 2.2 million and growing) has evolved from a drab, run-of-the-mill Soviet metropolis into the urban star of Central Asia. https://omgto3.com
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Along the way, the city has developed one of the world’s most beautiful metro systems, grown into a thriving banking and finance center, complemented its vintage bazaars with luxury boutiques and modern shopping malls and reshaped its traditional gastronomy into a nouvelle cuisine that’s drawing raves from foodies around the world.
Almaty is also evolving into the cultural and artistic hub of Central Asia. It’s already got several world-class museums (including a “secret” underground collection that doesn’t even have a name) and a dazzling new cultural center slated to open early next year.
“It’s an incredibly livable city,” says long-time American resident Dennis Keen, a historic preservation advocate and founder of Walking Almaty.
“Green and clean. You don’t need a car. The public transit here is fantastic. And it’s very much the center of contemporary art and dining in Central Asia.”
Keen adds that whenever he tells someone back home that he lives in Kazakhstan, “Borat” inevitably comes up. The movie’s title character doesn’t paint a very flattering portrait of the Central Asian nation. But nowadays one is tempted to think that if Borat visited Almaty now, he would say, “Very nice!”
Why this small city is the ‘eyeglasses capital’ of Japan
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Japan is famed for its skilled artisans, masters who maintain a commitment to tradition while modernizing production techniques in line with the development of new materials and processes.
Many places in the country have grown famous by focusing on specific crafts, from exquisite kimonos to perfectly designed knives. Among them is the small city of Sabae, in Fukui prefecture, about a 3.5-hour train ride from Tokyo. https://omgto3.com
омг ссылка
It’s widely known as Japan’s eyeglasses capital – and for good reason. Sabae produces over 90% of the frames manufactured in the country, according to the local government. Signs and objects shaped like eyeglasses can be found on city streets, and there’s even a museum and festival devoted to spectacles.
The art of making spectacles
Sabae, located on Japan’s main Honshu island near the city of Fukui, has been producing quality eyewear for more than a century.
It all started in 1905, when a local government official invited skilled eyeglasses artisans to come to the city to teach their craft, an attempt to create new opportunities for local farmers.
The move paid off. Today, Sabae has over 100 companies that collaborate to make pairs of glasses.
Though these studios use cutting-edge machinery to produce new frames made of metal and acetate, most stages still require the skilled hands and trained eyes of Sabae’s master artisans.
That includes Takeshi Yamae, a frame designer with Japanese brand Boston Club who has lived in the city for 17 years. He tells CNN one pair of glasses can involve more than 200 steps.
“I first design it, sketch it, then put it into my computer,” he says. “From the time I start designing, to the time I have the perfect product, it takes more than a year.”
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The research study recommend the experimental drug is safe since it had no result on high blood pressure and just increased heart rate slightly, claimed Arne Astrup of the College of Copenhagen, that led the study published in the journal Lancet. People taking NeuroSearch A/S’s obesity pill tesofensine shed two times as much weight as males and females using authorized weight-loss drugs, Danish researchers claimed on Thursday. Tesomet resulted in mathematical enhancements in the physical element ratings of SF-36 from week 4 to week 20; nonetheless, returned to near baseline at week 24, while the sugar pill team after an initially lowered physical component rating at week 8, returned to near standard at week 16 (Fig. 7A). Both groups had mathematical reductions in mental element score to better extent in Tesomet-treated individuals (Fig. 7B). In total amount, 35 patients were evaluated, of whom 21 distinct patients (16 women) satisfied qualification standards and were randomized (Fig. 2).
Cravings And Food Yearnings
A notable exception is the just recently accepted GLP1R agonist semaglutide 2.4 mg, which in phase III professional trials reduced body weight in individuals with excessive weight or overweight without diabetic issues after 68 weeks of treatment by − 14.9% relative to − 2.4% in placebo-treated controls38. The hypothalamus is the centre of neuroendocrine regulation of energy homeostasis and cravings. Maldevelopment of, or damage to, the crucial hypothalamic cores interferes with the worked with equilibrium between energy intake and expenditure leading, to rapid and too much weight gain.
Orlistat (Xenical ®), 120 mg, has actually been approved by the EMA and the FDA because 1998 and 1999, specifically, and its nonprescription formulation of 60 mg (Alli ®) is readily available in both the U.S.A. and Europe. As the lengthiest accredited anti-obesity medication suggested for long-term usage, orlistat is suggested for individuals ≥ 12 years of age [25] Figures 1 and 2 summarize the main system of activity for existing anti-obesity drugs used to deal with obesity (Table 1). More crucial than straightforward weight management though, is the capacity for a substantially much easier way to effect actual adjustment in the customer’s body composition. The very first benefit is most certainly the one that lots of people are mosting likely to use Tesofensine for, which’s its weight loss capacity. Its device includes the restraint of neurotransmitter reuptake, causing an increase in the degrees of serotonin, dopamine, and norepinephrine existing in the person’s system.
What Is Tesofensine?
To examine improvement in antipsychotic-induced weight gain, astudy randomized 103 subjects with schizophrenia that were obese or obese, had prediabetes and were treated with olanzapine or clozapine. The liraglutidegroup shed 5.3 kg greater than sugar pill, 64% developed typical sugar resistance, andblood stress and LDL cholesterol were significantly lowered [109] SAR showed a beneficial pharmacokinetics/pharmacodynamic account in these subjects including a lengthy half‐life (11– 18 h), which makes it appropriate for a once‐daily routine [65] Of note, a PET research study in 6 kind 2 diabetes mellitus clients aimed to assess target tenancy at glucagon receptor in liver and GLP-1R in pancreas after 17 and 20 days of treatment with SAR425899, specifically. The research demonstrated strong SAR binding to the GLP-1R, yet reduced tenancy at the glucagon receptor [66] The high failure price in addition to vague glucagon receptor-mediated effects in the latter study warrant better examination.
This leads to a substantial reduction of fat storage space, which is particularly valuable in weight-loss monitoring. With Tesofensine, you will certainly begin to experience a steady weight loss that’s much easier to preserve. Changes in body weight can impact the dosage requirements and metabolic process of medicine within the body. When body weight adjustments, the blood circulation system may be impacted, possibly changing the price at which drugs are transferred to the liver and kidneys for processing. These variables can influence the rate at which medications are absorbed, dispersed, and gotten rid of, requiring modifications to dose programs to ensure optimum performance and safety. Optimum dopamine levels have a positive effect on hunger law, metabolic process, and motivation.
From this perspective, in this evaluation, we go over excessive weight treatment strategies, focusing on pharmacological strategies with anti-obesity drugs approved for long-lasting usage in individuals with excessive weight. Nevertheless, healing methods for individuals with obesity are still not enough. The prevalence of obesity has actually steadily boosted in response to modifications in dietary and exercise patterns for the previous one decade, many plainly among adults in their 20s and 30s in South Korea. In 2018, the frequency of obesity, with a body mass index (BMI) of 25 kg/m2 or higher, amongst grown-up men and women was 45.4% and 26.5%, respectively. Among grownups in their 20s and 30s, 10.8% of men and 4.9% of women were overweight, with a BMI of 30 kg/m2 or better, which reflects a dramatic boost from the past decade [4] According to the that, more than 1.9 billion (39%) grownups aged 18 years and over were overweight and 650 million (13%) were overweight in 2016; the international prevalence of excessive weight has almost tripled in between 1975 and 2016 [5]
This action raises the levels of these neurotransmitters in the brain, which bring about decreased cravings, decreased calorie consumption, and boosted power expenditure. Additionally, Tesofensine likewise influences the reward pathways in the mind, making it less gratifying to consume food, bring about more reduction in food consumption. While tesofensine shows promise as a weight reduction therapy, it is essential to be familiar with its possible adverse effects.
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How a drab Soviet metropolis became Central Asia’s capital of cool
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
Since the collapse of the USSR, Kazakhstan’s largest city (population 2.2 million and growing) has evolved from a drab, run-of-the-mill Soviet metropolis into the urban star of Central Asia. https://omgto3.com
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Along the way, the city has developed one of the world’s most beautiful metro systems, grown into a thriving banking and finance center, complemented its vintage bazaars with luxury boutiques and modern shopping malls and reshaped its traditional gastronomy into a nouvelle cuisine that’s drawing raves from foodies around the world.
Almaty is also evolving into the cultural and artistic hub of Central Asia. It’s already got several world-class museums (including a “secret” underground collection that doesn’t even have a name) and a dazzling new cultural center slated to open early next year.
“It’s an incredibly livable city,” says long-time American resident Dennis Keen, a historic preservation advocate and founder of Walking Almaty.
“Green and clean. You don’t need a car. The public transit here is fantastic. And it’s very much the center of contemporary art and dining in Central Asia.”
Keen adds that whenever he tells someone back home that he lives in Kazakhstan, “Borat” inevitably comes up. The movie’s title character doesn’t paint a very flattering portrait of the Central Asian nation. But nowadays one is tempted to think that if Borat visited Almaty now, he would say, “Very nice!”
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‘We barely made it out’: Californians desperately flee their homes amid raging wildfires
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Terrie Morin, 60, and her husband, Dave, were at the barber shop when they heard about a raging wildfire making headway toward their Camarillo home on Wednesday morning.
The couple were hosting two guests at the time, but because their guests worked late, Morin suspected they slept through the residence’s fire alarms.
“I run in the house, and I’m banging on the door, and they did not hear me. They were knocked out,” Morin told CNN. “Get the dog. Get out of here. You don’t have time, just get out!” she recalled telling them. https://omgto3.com
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Ten minutes later, Dave noticed sparks in their backyard. The temperature was also picking up.
“It was hot. It was so hot,” Morin recalled.
Dozens of homes in California’s Ventura County were set alight in a sweeping wildfire that burned through thousands of acres of land in just a matter of hours midweek –– prompting authorities to send more than 14,000 evacuation notices across the region.
The Mountain Fire began early Wednesday and was driven by winds gusting over 60 mph. The flames have seared through more than 20,485 acres of land, according to Cal Fire.
The families who evacuated at a moment’s notice, some who say they have now lost their homes, must deal with other losses that can also be devastating, from daily essentials like medications and shoes to meaningful possessions such as sculptures and artwork, to treasured keepsakes from the birth of a child or the life of a parent.
At least 132 properties have been destroyed by the fire, while 88 have been left damaged, Ventura County Fire Department officials said Thursday evening. Ten damage inspection teams have been deployed to inspect structures along the path of the blaze.
Ten people endured non-life-threatening injuries from the Mountain Fire, which are mostly related to smoke inhalation, Ventura County Sheriff Jim Fryhoff said.
How a drab Soviet metropolis became Central Asia’s capital of cool
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
Since the collapse of the USSR, Kazakhstan’s largest city (population 2.2 million and growing) has evolved from a drab, run-of-the-mill Soviet metropolis into the urban star of Central Asia. https://omgto3.com
омг ссылка
Along the way, the city has developed one of the world’s most beautiful metro systems, grown into a thriving banking and finance center, complemented its vintage bazaars with luxury boutiques and modern shopping malls and reshaped its traditional gastronomy into a nouvelle cuisine that’s drawing raves from foodies around the world.
Almaty is also evolving into the cultural and artistic hub of Central Asia. It’s already got several world-class museums (including a “secret” underground collection that doesn’t even have a name) and a dazzling new cultural center slated to open early next year.
“It’s an incredibly livable city,” says long-time American resident Dennis Keen, a historic preservation advocate and founder of Walking Almaty.
“Green and clean. You don’t need a car. The public transit here is fantastic. And it’s very much the center of contemporary art and dining in Central Asia.”
Keen adds that whenever he tells someone back home that he lives in Kazakhstan, “Borat” inevitably comes up. The movie’s title character doesn’t paint a very flattering portrait of the Central Asian nation. But nowadays one is tempted to think that if Borat visited Almaty now, he would say, “Very nice!”
Никогда бы не подумал, что, участвуя в кооперативе «Бест Вей», столкнусь с такой несправедливостью. Мы стали заложниками ситуации, когда из нас пытаются сделать участников преступной схемы. Я вложил свои деньги, надеясь на то, что смогу приобрести жилье, и до недавнего времени был уверен в том, что это возможно. Но теперь кооператив под угрозой уничтожения, а наши сбережения заморожены. Следственные органы даже не пытаются разобраться, просто обвиняют и блокируют счета. У нас не осталось другого выхода, кроме как отстаивать свои права в суде. Мы не преступники, и я уверен, что правда на нашей стороне. Мы не позволим уничтожить наше будущее!
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Why this small city is the ‘eyeglasses capital’ of Japan
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Japan is famed for its skilled artisans, masters who maintain a commitment to tradition while modernizing production techniques in line with the development of new materials and processes.
Many places in the country have grown famous by focusing on specific crafts, from exquisite kimonos to perfectly designed knives. Among them is the small city of Sabae, in Fukui prefecture, about a 3.5-hour train ride from Tokyo.
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It’s widely known as Japan’s eyeglasses capital – and for good reason. Sabae produces over 90% of the frames manufactured in the country, according to the local government. Signs and objects shaped like eyeglasses can be found on city streets, and there’s even a museum and festival devoted to spectacles.
The art of making spectacles
Sabae, located on Japan’s main Honshu island near the city of Fukui, has been producing quality eyewear for more than a century.
It all started in 1905, when a local government official invited skilled eyeglasses artisans to come to the city to teach their craft, an attempt to create new opportunities for local farmers.
The move paid off. Today, Sabae has over 100 companies that collaborate to make pairs of glasses.
Though these studios use cutting-edge machinery to produce new frames made of metal and acetate, most stages still require the skilled hands and trained eyes of Sabae’s master artisans.
That includes Takeshi Yamae, a frame designer with Japanese brand Boston Club who has lived in the city for 17 years. He tells CNN one pair of glasses can involve more than 200 steps.
“I first design it, sketch it, then put it into my computer,” he says. “From the time I start designing, to the time I have the perfect product, it takes more than a year.”
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
Since the collapse of the USSR, Kazakhstan’s largest city (population 2.2 million and growing) has evolved from a drab, run-of-the-mill Soviet metropolis into the urban star of Central Asia.
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Along the way, the city has developed one of the world’s most beautiful metro systems, grown into a thriving banking and finance center, complemented its vintage bazaars with luxury boutiques and modern shopping malls and reshaped its traditional gastronomy into a nouvelle cuisine that’s drawing raves from foodies around the world.
Almaty is also evolving into the cultural and artistic hub of Central Asia. It’s already got several world-class museums (including a “secret” underground collection that doesn’t even have a name) and a dazzling new cultural center slated to open early next year.
“It’s an incredibly livable city,” says long-time American resident Dennis Keen, a historic preservation advocate and founder of Walking Almaty.
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Keen adds that whenever he tells someone back home that he lives in Kazakhstan, “Borat” inevitably comes up. The movie’s title character doesn’t paint a very flattering portrait of the Central Asian nation. But nowadays one is tempted to think that if Borat visited Almaty now, he would say, “Very nice!”
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Why this small city is the ‘eyeglasses capital’ of Japan
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Japan is famed for its skilled artisans, masters who maintain a commitment to tradition while modernizing production techniques in line with the development of new materials and processes.
Many places in the country have grown famous by focusing on specific crafts, from exquisite kimonos to perfectly designed knives. Among them is the small city of Sabae, in Fukui prefecture, about a 3.5-hour train ride from Tokyo.
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омг ссылка
It’s widely known as Japan’s eyeglasses capital – and for good reason. Sabae produces over 90% of the frames manufactured in the country, according to the local government. Signs and objects shaped like eyeglasses can be found on city streets, and there’s even a museum and festival devoted to spectacles.
The art of making spectacles
Sabae, located on Japan’s main Honshu island near the city of Fukui, has been producing quality eyewear for more than a century.
It all started in 1905, when a local government official invited skilled eyeglasses artisans to come to the city to teach their craft, an attempt to create new opportunities for local farmers.
The move paid off. Today, Sabae has over 100 companies that collaborate to make pairs of glasses.
Though these studios use cutting-edge machinery to produce new frames made of metal and acetate, most stages still require the skilled hands and trained eyes of Sabae’s master artisans.
That includes Takeshi Yamae, a frame designer with Japanese brand Boston Club who has lived in the city for 17 years. He tells CNN one pair of glasses can involve more than 200 steps.
“I first design it, sketch it, then put it into my computer,” he says. “From the time I start designing, to the time I have the perfect product, it takes more than a year.”
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The research study recommend the experimental drug is safe since it had no result on high blood pressure and just increased heart rate slightly, claimed Arne Astrup of the College of Copenhagen, that led the study published in the journal Lancet. People taking NeuroSearch A/S’s obesity pill tesofensine shed two times as much weight as males and females using authorized weight-loss drugs, Danish researchers claimed on Thursday. Tesomet resulted in mathematical enhancements in the physical element ratings of SF-36 from week 4 to week 20; nonetheless, returned to near baseline at week 24, while the sugar pill team after an initially lowered physical component rating at week 8, returned to near standard at week 16 (Fig. 7A). Both groups had mathematical reductions in mental element score to better extent in Tesomet-treated individuals (Fig. 7B). In total amount, 35 patients were evaluated, of whom 21 distinct patients (16 women) satisfied qualification standards and were randomized (Fig. 2).
Cravings And Food Yearnings
A notable exception is the just recently accepted GLP1R agonist semaglutide 2.4 mg, which in phase III professional trials reduced body weight in individuals with excessive weight or overweight without diabetic issues after 68 weeks of treatment by − 14.9% relative to − 2.4% in placebo-treated controls38. The hypothalamus is the centre of neuroendocrine regulation of energy homeostasis and cravings. Maldevelopment of, or damage to, the crucial hypothalamic cores interferes with the worked with equilibrium between energy intake and expenditure leading, to rapid and too much weight gain.
Orlistat (Xenical ®), 120 mg, has actually been approved by the EMA and the FDA because 1998 and 1999, specifically, and its nonprescription formulation of 60 mg (Alli ®) is readily available in both the U.S.A. and Europe. As the lengthiest accredited anti-obesity medication suggested for long-term usage, orlistat is suggested for individuals ≥ 12 years of age [25] Figures 1 and 2 summarize the main system of activity for existing anti-obesity drugs used to deal with obesity (Table 1). More crucial than straightforward weight management though, is the capacity for a substantially much easier way to effect actual adjustment in the customer’s body composition. The very first benefit is most certainly the one that lots of people are mosting likely to use Tesofensine for, which’s its weight loss capacity. Its device includes the restraint of neurotransmitter reuptake, causing an increase in the degrees of serotonin, dopamine, and norepinephrine existing in the person’s system.
What Is Tesofensine?
To examine improvement in antipsychotic-induced weight gain, astudy randomized 103 subjects with schizophrenia that were obese or obese, had prediabetes and were treated with olanzapine or clozapine. The liraglutidegroup shed 5.3 kg greater than sugar pill, 64% developed typical sugar resistance, andblood stress and LDL cholesterol were significantly lowered [109] SAR showed a beneficial pharmacokinetics/pharmacodynamic account in these subjects including a lengthy half‐life (11– 18 h), which makes it appropriate for a once‐daily routine [65] Of note, a PET research study in 6 kind 2 diabetes mellitus clients aimed to assess target tenancy at glucagon receptor in liver and GLP-1R in pancreas after 17 and 20 days of treatment with SAR425899, specifically. The research demonstrated strong SAR binding to the GLP-1R, yet reduced tenancy at the glucagon receptor [66] The high failure price in addition to vague glucagon receptor-mediated effects in the latter study warrant better examination.
This leads to a substantial reduction of fat storage space, which is particularly valuable in weight-loss monitoring. With Tesofensine, you will certainly begin to experience a steady weight loss that’s much easier to preserve. Changes in body weight can impact the dosage requirements and metabolic process of medicine within the body. When body weight adjustments, the blood circulation system may be impacted, possibly changing the price at which drugs are transferred to the liver and kidneys for processing. These variables can influence the rate at which medications are absorbed, dispersed, and gotten rid of, requiring modifications to dose programs to ensure optimum performance and safety. Optimum dopamine levels have a positive effect on hunger law, metabolic process, and motivation.
From this perspective, in this evaluation, we go over excessive weight treatment strategies, focusing on pharmacological strategies with anti-obesity drugs approved for long-lasting usage in individuals with excessive weight. Nevertheless, healing methods for individuals with obesity are still not enough. The prevalence of obesity has actually steadily boosted in response to modifications in dietary and exercise patterns for the previous one decade, many plainly among adults in their 20s and 30s in South Korea. In 2018, the frequency of obesity, with a body mass index (BMI) of 25 kg/m2 or higher, amongst grown-up men and women was 45.4% and 26.5%, respectively. Among grownups in their 20s and 30s, 10.8% of men and 4.9% of women were overweight, with a BMI of 30 kg/m2 or better, which reflects a dramatic boost from the past decade [4] According to the that, more than 1.9 billion (39%) grownups aged 18 years and over were overweight and 650 million (13%) were overweight in 2016; the international prevalence of excessive weight has almost tripled in between 1975 and 2016 [5]
This action raises the levels of these neurotransmitters in the brain, which bring about decreased cravings, decreased calorie consumption, and boosted power expenditure. Additionally, Tesofensine likewise influences the reward pathways in the mind, making it less gratifying to consume food, bring about more reduction in food consumption. While tesofensine shows promise as a weight reduction therapy, it is essential to be familiar with its possible adverse effects.
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
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How a drab Soviet metropolis became Central Asia’s capital of cool
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Several cities around the globe have reinvented themselves in recent years, but none more successfully than Almaty.
Since the collapse of the USSR, Kazakhstan’s largest city (population 2.2 million and growing) has evolved from a drab, run-of-the-mill Soviet metropolis into the urban star of Central Asia.
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Along the way, the city has developed one of the world’s most beautiful metro systems, grown into a thriving banking and finance center, complemented its vintage bazaars with luxury boutiques and modern shopping malls and reshaped its traditional gastronomy into a nouvelle cuisine that’s drawing raves from foodies around the world.
Almaty is also evolving into the cultural and artistic hub of Central Asia. It’s already got several world-class museums (including a “secret” underground collection that doesn’t even have a name) and a dazzling new cultural center slated to open early next year.
“It’s an incredibly livable city,” says long-time American resident Dennis Keen, a historic preservation advocate and founder of Walking Almaty.
“Green and clean. You don’t need a car. The public transit here is fantastic. And it’s very much the center of contemporary art and dining in Central Asia.”
Keen adds that whenever he tells someone back home that he lives in Kazakhstan, “Borat” inevitably comes up. The movie’s title character doesn’t paint a very flattering portrait of the Central Asian nation. But nowadays one is tempted to think that if Borat visited Almaty now, he would say, “Very nice!”
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